Products for Research Use Only
RegisterLogin

FN-1501

CAT: 0013-GTR19156137-08Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19156137-08Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively) . FN-1501 also has anticancer activity.
CAS Number
1429515-59-2
Purity
>98% (HPLC)
Solubility
DMSO: 45 mg/mL (104.29 mM)
Smiles
O=C (C1=NNC=C1NC2=NC=NC3=C2C=CN3) NC4=CC=C (CN5CCN (C) CC5) C=C4
Molecular Formula
C22H25N9O
Molecular Weight
431.49
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Fn-1501

CDK2/4/6/FLT3 Inhibitor FN-1501 is a small molecule multi-kinase inhibitor of cyclin-dependent kinase (CDK) subtypes 2 (CDK2), 4 (CDK4), and 6 (CDK6) and FMS-related tyrosine kinase 3 (FLT3, FLK2, STK1), with potential antineoplastic activity. Upon intravenous administration, CDK2/4/6/FLT3 inhibitor FN-1501 binds to and inhibits CDK2, CDK4, and CDK6, as well as FLT3. This may induce apoptosis and inhibit tumor cell proliferation in cancer cells that overexpress these kinases. CDKs are serine/threonine kinases that assist in cell cycle regulation and cellular proliferation. FLT3, a class III tyrosine kinase receptor, is overexpressed or mutated in many cancer types.

CAS Number1429515-59-2
PubChem CID72195175
IUPAC NameN-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide
Molecular FormulaC22H25N9O
Molecular Weight431.5
XLogP2.2
Topological Polar Surface Area118
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity621
SMILES
CN1CCN(CC1)CC2=CC=C(C=C2)NC(=O)C3=C(C=NN3)NC4=NC=NC5=C4C=CN5
InChI
InChI=1S/C22H25N9O/c1-30-8-10-31(11-9-30)13-15-2-4-16(5-3-15)27-22(32)19-18(12-26-29-19)28-21-17-6-7-23-20(17)24-14-25-21/h2-7,12,14H,8-11,13H2,1H3,(H,26,29)(H,27,32)(H2,23,24,25,28)
InChIKey
VXLAKHWYGRKCGI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Fn-1501
CAS: 1429515-59-2
CID: 72195175
Formula: C22H25N9O
MW: 431.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight431.5
XLogP32.2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass431.21820645
Monoisotopic Mass431.21820645
Topological Polar Surface Area118 Ų
Heavy Atom Count32
Formal Charge0
Complexity621
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19031096-01FN-439
GTR18603937-01FN Rabbit pAb
GTR19207068-01(Rac) -AMXT-1501 4HCl
GTR18605343-01FN Mouse mAb
GTR19232533-01QM-FN-SO3
GTR19231219-01FN-439 TFA
GTR18855029Mouse FN ELISA Kit
GTR18805776-01Rat FN ELISA Kit
GTR19299246-01QM-FN-SO3 ammonium
GTR18804350-01Mouse FN ELISA Kit

Alternative Products

CatalogName
BA3777-50FN-1501
A13559-25FN-1501 25mg
A13559-10FN-1501 10mg
A13559-100FN-1501 100mg
A13559-1FN-1501 1mg
A13559-50FN-1501 50mg
A13559-5FN-1501 5mg
HY-130981FN-1501-propionic acid
A13559-10mM-DFN-1501 10mM * 1mL in DMSO
HY-P991365DS-1501

Popular Products