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UCB-9260

CAT: 0013-GTR19156072-08Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156072-08Size:100 mg
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Description
UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer. (In Vitro) :UCB-9260 (0-10 μM) inhibits NF-κB with a geometric mean IC50 of 202 nM after TNF (10 pM) stimulation in in Hek-293 cells.UCB-9260 inhibits TNF-dependent cytotoxicity with a geometric mean IC50 of 116 nM and a geometric mean IC50 of 120 nM, using human and mouse TNF, respectively. (In Vivo) :UCB-9260 (0-10 μM) inhibits NF-κB with a geometric mean IC50 of 202 nM after TNF (10 pM) stimulation in in Hek-293 cells.UCB-9260 inhibits TNF-dependent cytotoxicity with a geometric mean IC50 of 116 nM and a geometric mean IC50 of 120 nM, using human and mouse TNF, respectively.
CAS Number
1515888-53-5
Purity
>98% (HPLC)
Solubility
DMSO:10 mM
Smiles
OC (C1=CC=NC=C1) C2=NC3=CC=C (C4=CN (C) N=C4) C=C3N2CC5=CC (C) =CC=C5C
Molecular Formula
C26H25N5O
Molecular Weight
423.51
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

[1-[(2,5-Dimethylphenyl)methyl]-6-(1-methylpyrazol-4-yl)benzimidazol-2-yl]-pyridin-4-ylmethanol
CAS Number1515888-53-5
PubChem CID72700327
IUPAC Name[1-[(2,5-dimethylphenyl)methyl]-6-(1-methylpyrazol-4-yl)benzimidazol-2-yl]-pyridin-4-ylmethanol
Molecular FormulaC26H25N5O
Molecular Weight423.5
XLogP3.5
Topological Polar Surface Area68.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count32
Formal Charge0
Complexity613
SMILES
CC1=CC(=C(C=C1)C)CN2C3=C(C=CC(=C3)C4=CN(N=C4)C)N=C2C(C5=CC=NC=C5)O
InChI
InChI=1S/C26H25N5O/c1-17-4-5-18(2)21(12-17)16-31-24-13-20(22-14-28-30(3)15-22)6-7-23(24)29-26(31)25(32)19-8-10-27-11-9-19/h4-15,25,32H,16H2,1-3H3
InChIKey
RZGFWGNCSYUEPR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of [1-[(2,5-Dimethylphenyl)methyl]-6-(1-methylpyrazol-4-yl)benzimidazol-2-yl]-pyridin-4-ylmethanol
CAS: 1515888-53-5
CID: 72700327
Formula: C26H25N5O
MW: 423.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight423.5
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass423.20591044
Monoisotopic Mass423.20591044
Topological Polar Surface Area68.8 Ų
Heavy Atom Count32
Formal Charge0
Complexity613
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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