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Etalocib

CAT: 0013-GTR19156006-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156006-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Etalocib is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotriene B4 (LTB4) receptor or directly through 5'-lipoxygenase. It has antineoplastic activities. (In Vitro) :Etalocib (LY293111) elicits a concentration-dependent inhibition of LTB4 induced CD11b up-regulation.Etalocib (LY293111) is an extremely potent and selective antagonist of human neutrophil function in vitro.Etalocib (LY293111, 250 and 500 nM, 24-72 h) induces apoptosis and inhibits proliferation in human pancreatic cancer cells. (In Vivo) :Etalocib (LY293111) produces a dose-related inhibition of acute leukotriene B4-induced airway obstruction when administered i.v. (ED50=14 μg/kg) or p.o. (ED50=0.4 mg/kg) .Etalocib (LY293111, 10 mg/kg) inhibits A23187-induced lung inflammatory changes at 1 h.Etalocib (LY293111, 250 mg/kg/day, orally) inhibits growth of human pancreatic cancer xenografts in athymic mice.
CAS Number
161172-51-6
Product Name Alternative
LY293111 | VML295
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (183.62 mM; Need ultrasonic)
Smiles
O=C (O) C1=CC=CC=C1OC2=CC=CC (OCCCOC3=C (CC) C=C (C4=CC=C (F) C=C4) C (O) =C3) =C2CCC
Molecular Formula
C33H33FO6
Molecular Weight
544.6
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
BUP08070-01Etalocib
HY-13628AEtalocib (sodium)
T201014-01Etalocib sodium
HY-13628R-01Etalocib (Standard)
A22473-10Etalocib (LY293111) 10mg
A22473-5Etalocib (LY293111) 5mg
A22473-50Etalocib (LY293111) 50mg
A22473-200Etalocib (LY293111) 200mg
A22473-100Etalocib (LY293111) 100mg
A22473-1Etalocib (LY293111) 1mg

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