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Etalocib

CAT: 0804-HY-13628-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13628-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Etalocib (LY293111), an orally active leukotriene B4 receptor antagonist, inhibits the binding of [3H]LTB4, with a Ki of 25 nM. Etalocib (LY293111) prevents LTB4-induced calcium mobilization with an lC50 of 20 nM. Etalocib (LY293111) induces apoptosis[1][2][3].
CAS Number
161172-51-6
Product Name Alternative
LY293111; VML 295
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Leukotriene Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/etalocib.html
Purity
99.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=CC=C1OC2=CC=CC(OCCCOC3=C(CC)C=C(C4=CC=C(F)C=C4)C(O)=C3)=C2CCC
Molecular Formula
C33H33FO6
Molecular Weight
544.61
Precautions
H302, H315, H319, H335
References & Citations
[1]P Marder, et al. Blockade of Human Neutrophil Activation by 2-[2-propyl-3-[3-[2-ethyl-4- (4-fluorophenyl) -5- Hydroxyphenoxy]propoxy]phenoxy]benzoic Acid (LY293111), a Novel Leukotriene B4 Receptor Antagonist. Biochem Pharmacol. 1995 May 26;49 (11) :1683-90.|[2]S A Silbaugh, et al. Pharmacologic Actions of the Second Generation Leukotriene B4 Receptor Antagonist LY29311: In Vivo Pulmonary Studies. Naunyn Schmiedebergs Arch Pharmacol. 2000 Apr;361 (4) :397-404.|[3]Wei-Gang Tong, et al. Leukotriene B4 Receptor Antagonist LY293111 Inhibits Proliferation and Induces Apoptosis in Human Pancreatic Cancer Cells. Clin Cancer Res. 2002 Oct;8 (10) :3232-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
LTB4

Alternative Products

CatalogName
BUP08070-01Etalocib
GTR19239779-01Etalocib sodium
A22473-10Etalocib (LY293111) 10mg
A22473-5Etalocib (LY293111) 5mg
A22473-50Etalocib (LY293111) 50mg
A22473-200Etalocib (LY293111) 200mg
A22473-100Etalocib (LY293111) 100mg
A22473-1Etalocib (LY293111) 1mg
A22473-25Etalocib (LY293111) 25mg
A22473-0.5Etalocib (LY293111) 0.5mg

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