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Metipranolol

CAT: 0013-GTR19155883-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19155883-02Size:500 mg
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Description
Metipranolol is a β-adrenergic receptor antagonist that is given orally for the treatment of hypertension and also applied topically to the cornea for treating glaucoma. (In Vivo) :At postnatal day 35 (P35), rd10 mice given daily subcutaneous injections of 40 mg/kg of Metipranolol has reduction in markers of nitrosative stress, fewer TUNEL-positive cells, increased outer nuclear layer thickness, and substantially more staining for rhodopsin. At P50, Metipranolol-treated rd10 mice has decreased 3-nitrotyrosine staining in the retina, increased immunostaining for cone arrestin, a marker for cone photoreceptors, and significantly higher scotopic and photopic b-wave amplitudes at the highest stimulus intensity. At P65, cone density is significantly higher in Metipranolol-treated versus vehicle-injected rd10 mice.
CAS Number
22664-55-7
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:10 mM
Smiles
CC1=CC (=C (C (=C1OC (=O) C) C) C) OCC (CNC (C) C) O
Molecular Formula
C17H27NO4
Molecular Weight
309.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Metipranolol

Metipranolol is 3-(Propan-2-ylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by a 4-acetoxy-2,3,5-trimethylphenoxy group. A non-cardioselective beta-blocker, it is used to lower intra-ocular pressure in the management of open-angle glaucoma. It has a role as a beta-adrenergic antagonist, an antihypertensive agent, an anti-arrhythmia drug and an antiglaucoma drug. It is a propanolamine, an aromatic ether, an acetate ester and a secondary amino compound.

CAS Number22664-55-7
PubChem CID31477
IUPAC Name[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]-2,3,6-trimethylphenyl] acetate
Molecular FormulaC17H27NO4
Molecular Weight309.4
XLogP2.7
Topological Polar Surface Area67.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count22
Formal Charge0
Complexity348
SMILES
CC1=CC(=C(C(=C1OC(=O)C)C)C)OCC(CNC(C)C)O
InChI
InChI=1S/C17H27NO4/c1-10(2)18-8-15(20)9-21-16-7-11(3)17(22-14(6)19)13(5)12(16)4/h7,10,15,18,20H,8-9H2,1-6H3
InChIKey
BQIPXWYNLPYNHW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Metipranolol
CAS: 22664-55-7
CID: 31477
Formula: C17H27NO4
MW: 309.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight309.4
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass309.19400834
Monoisotopic Mass309.19400834
Topological Polar Surface Area67.8 Ų
Heavy Atom Count22
Formal Charge0
Complexity348
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M24030-01Metipranolol
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HY-121567RMetipranolol (Standard)

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