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Arhalofenate

CAT: 0013-GTR19155798-07Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19155798-07Size:500 mg
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Description
Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes. (In Vitro) :Arhalofenate (MBX 102) is a prodrug ester, that is rapidly and completely modified in vivo by non-specific serum esterases to the mature free acid form Arhalofenate (MBX 102) acid. Arhalofenate (MBX 102) shows a dose-dependent activation of mouse GAL4-PPAR-γ with EC50s of appr 12 μM. (In Vivo) :Arhalofenate (MBX 102) (100 mg/kg, p.o.) significantly increases the glucose infusion rate and decreases hepatic glucose output in the clamped state in Zucker Diabetic Fatty (ZDF) rats. Arhalofenate (MBX 102) (60 mg/kg) leads to a dramatic decrease in plasma and also results in a dose-dependent, significant decrease in the insulin resistance indexinsulin levels. Arhalofenate (MBX 102) (100 mg/kg, p.o.) significantly decreases triglyceride, free fatty acid, and cholesterol levels in ZDF rats. MBX-102 significantly reduces fasting blood glucose, confirming that Arhalofenate (MBX 102) is an efficacious antidiabetic agent. Arhalofenate (MBX 102) (100 mg/kg, p.o.) also significantly lowers fasting plasma insulin, and robustly decreases fasting plasma triglycerides after 32 days of treatment in Zucker Fatty (ZF) rats.
CAS Number
24136-23-0
Product Name Alternative
MBX 102 | JNJ 39659100
Purity
>98% (HPLC)
Solubility
DMSO:10 mM
Smiles
CC (=O) NCCOC (=O) [C@@H] (C1=CC=C (C=C1) Cl) OC2=CC=CC (=C2) C (F) (F) F
Molecular Formula
C19H17ClF3NO4
Molecular Weight
415.79
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Arhalofenate

Arhalofenate has been investigated for the treatment of Gout and Hyperuricemia.

CAS Number24136-23-0
PubChem CID12082259
IUPAC Name2-acetamidoethyl (2R)-2-(4-chlorophenyl)-2-[3-(trifluoromethyl)phenoxy]acetate
Molecular FormulaC19H17ClF3NO4
Molecular Weight415.8
XLogP4.3
Topological Polar Surface Area64.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Heavy Atom Count28
Formal Charge0
Complexity524
SMILES
CC(=O)NCCOC(=O)[C@@H](C1=CC=C(C=C1)Cl)OC2=CC=CC(=C2)C(F)(F)F
InChI
InChI=1S/C19H17ClF3NO4/c1-12(25)24-9-10-27-18(26)17(13-5-7-15(20)8-6-13)28-16-4-2-3-14(11-16)19(21,22)23/h2-8,11,17H,9-10H2,1H3,(H,24,25)/t17-/m1/s1
InChIKey
BJBCSGQLZQGGIQ-QGZVFWFLSA-N
Chemical Structure
2D Structure
2D structure of Arhalofenate
CAS: 24136-23-0
CID: 12082259
Formula: C19H17ClF3NO4
MW: 415.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight415.8
XLogP34.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass415.0798202
Monoisotopic Mass415.0798202
Topological Polar Surface Area64.6 Ų
Heavy Atom Count28
Formal Charge0
Complexity524
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-14831-01Arhalofenate
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A21135-500Arhalofenate 500mg
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A21135-100Arhalofenate 100mg
A21135-25Arhalofenate 25mg
A21135-10Arhalofenate 10mg
A21135-50Arhalofenate 50mg
A21135-10mM-DArhalofenate 10mM * 1mL in DMSO

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