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Arhalofenate

CAT: 0804-HY-14831-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14831-01Size:1 mg
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Description
Arhalofenate (MBX 102) is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR) -γ, used for the treatment of type 2 diabetes.
CAS Number
24136-23-0
Product Name Alternative
MBX 102; JNJ 39659100
UNSPSC
12352005
Hazard Statement
H301-H319-H410
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/MBX_102.html
Purity
99.85
Solubility
10 mM in DMSO
Smiles
O=C(OCCNC(C)=O)[C@@H](C1=CC=C(Cl)C=C1)OC2=CC=CC(C(F)(F)F)=C2
Molecular Formula
C19H17ClF3NO4
Molecular Weight
415.79
Precautions
P264-P270-P273-P280-P305+P351+P338-P330-P391-P405-P501
References & Citations
[1]Gregoire FM, et al. MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema. Mol Endocrinol. 2009 Jul;23 (7) :975-88.|[2]Chandalia A, et al. MBX-102/JNJ39659100, a novel non-TZD selective partial PPAR-γ agonist lowers triglyceride independently of PPAR-α activation. PPAR Res. 2009;2009:706852.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
PPARγ