Products for Research Use Only
RegisterLogin

M-31850

CAT: 0013-GTR19155707-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19155707-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor (human HexA and human HexB with IC50s of 6.0 μM and 3.1 μM, respectively) . IT also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a Ki of 2.5 μM. (In Vitro) :M-31850 shows some activity towards Jack Bean Hex (JBHex) and bacterial Hex from Streptomyces plicatus (SpHex) (IC50 of 280 μM and >500 μM for JBHex and SpHex, respectively) .M-31850 produces a dose dependent increase in MUG hydrolysis (Hex S levels) in lysates from treated infantile Sandhoff disease (ISD) cells.M-31850 increases the half-life of the mutant Hex A from Adult forms of Tay-Sachs (ATSD) cells more than two-fold at 44° C, relative to the enzyme heated in the presence of DMSO. M-31850 acts as a classic competitive inhibitor of Hex (Km increases and Vmax is unaffected by increasing amounts of M-31850), with a Ki of 0.8 μM.
CAS Number
281224-40-6
Product Name Alternative
1H-Benz[de]isoquinoline-1,3 (2H) -dione, 2,2'- (iminodi-2,1-ethanediyl) bis-
Purity
>98% (HPLC)
Solubility
DMSO:5 mg/mL (10.79 mM; ultrasonic and adjust pH to 6 with HCl)
Smiles
C1=CC2=C3C (=C1) C (=O) N (C (=O) C3=CC=C2) CCNCCN4C (=O) C5=CC=CC6=C5C (=CC=C6) C4=O
Molecular Formula
C28H21N3O4
Molecular Weight
463.48
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Related Products

CatalogName
GTR19223351-01Lopinavir M-3/M-4
GTR19010186-01Granzyme M
GTR18147655SARS-M
GTR19201948-01M 15
GTR19231621-01Excavatin M
GTR19229720-01M-Tyramine
GTR19224614-01M-Ethoxybenzaldehyde
GTR19223115-01M-Hydroxybenzylpiperazine
GTR19223103-01M-Methylphenylacetonitrile
GTR19221520-01M-Chloramphenicol

Alternative Products

CatalogName
HY-104050-01M-31850
TRC-Q116570-500MGm,m-Quaterphenyl
BAA16618M, M-Quaterphenyl
EK0445m.M-CSF
sc-38287-PRHnRNP M (m) -PR
sc-153327Selenoprotein M siRNA (m)
sc-60762Granzyme M siRNA (m)
sc-149201M-RIP siRNA (m)
sc-41858-PRM-Ras (m) -PR
sc-36051NF-M siRNA (m)

Popular Products