Products for Research Use Only
RegisterLogin

Plecanatide

CAT: 0013-GTR19155735-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19155735-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist. (In Vitro) :Plecanatide (1 nM-10 μM) activates GC-C receptor to stimulate cyclic guanosine monophosphate (cGMP) synthesis in a dose-dependent manner with EC50 of 190 nM in T84 cells. (In Vivo) :Plecanatide (0.5 and 2.5 mg/kg, p.o.) ameliorates spontaneous and chemically induced colitis after treatment for 7 days in BALB/c mice, and 14 days in TCRα-/- mice.Plecanatide (0.005-5 mg/kg, once daily for 7 days) also shows anti-inflammatory activity in dextran sulfate sodium (DSS) and trinitrobenzene sulfonic (TNBS) -induced colitis in BDF-1 mice.
CAS Number
467426-54-6
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (59.46 mM)
Smiles
CC (C) C[C@H] (NC ([C@H]1NC (CNC ([C@@H] (NC ([C@H]2NC ([C@H] (C) NC ([C@@H] (NC ([C@H] (CC (N) =O) NC ([C@@H] (NC ([C@H] (CSSC1) NC ([C@H] (CC (C) C) NC ([C@H] (CCC (O) =O) NC ([C@H] (CSSC2) NC ([C@H] (CCC (O) =O) NC ([C@H] (CC (O) =O) NC ([C@@H] (N) CC (N) =O) =O) =O) =O) =O) =O) =O) =O) C (C) C) =O) =O) C (C) C) =O) =O) =O) [C@@H] (C) O) =O) =O) =O) C (O) =O
Molecular Formula
C65H104N18O26S4
Molecular Weight
1681.89
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
M24417-01Plecanatide
HY-108741A-01Plecanatide (acetate)
HY-108741RPlecanatide (Standard)
MBS3845823-01Plecanatide acetate
A21393-50Plecanatide acetate 50mg
A21393-25Plecanatide acetate 25mg
A21393-1Plecanatide acetate 1mg
A21393-100Plecanatide acetate 100mg
A21393-10Plecanatide acetate 10mg
A21393-5Plecanatide acetate 5mg

Popular Products