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BI-0115

CAT: 0013-GTR19155540-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19155540-01Size:200 mg
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Description
BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.
CAS Number
4929-23-1
Purity
>98% (HPLC)
Solubility
DMSO:10 mM
Smiles
O=C1N (CCC) C2=CC=CN=C2NC3=C1C=CC (Cl) =C3
Molecular Formula
C15H14ClN3O
Molecular Weight
287.747
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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