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MK-0354

CAT: 0013-GTR19153765-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19153765-01Size:100 mg
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Description
MK-0354 is a partial agonist of GPR109a receptor, for hGPR109a/ mGPR109a with EC50 of 1.65/1.08 μM, showed no activation of GPR109b.
CAS Number
851776-28-8
Purity
>98%
Smiles
C12=C (CCC2) C (C3=NN=NN3) =NN1
Molecular Formula
C7H8N6
Molecular Weight
176.1786
Notes
For research use only.

Chemical Information

MK-0354

MK-0354, is an orally administered drug candidate under development by Merck for the treatment of atherosclerosis and related disorders. It targets G protein-coupled receptor, or GPCR, that have the potential to regulate plasma lipid profiles, including HDL, or the good cholesterol, similar to the therapeutic action of niacin.

CAS Number851776-28-8
PubChem CID11159621
IUPAC Name3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[d]pyrazole
Molecular FormulaC7H8N6
Molecular Weight176.18
XLogP0.2
Topological Polar Surface Area83.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count13
Formal Charge0
Complexity197
SMILES
C1CC2=C(C1)NN=C2C3=NNN=N3
InChI
InChI=1S/C7H8N6/c1-2-4-5(3-1)8-9-6(4)7-10-12-13-11-7/h1-3H2,(H,8,9)(H,10,11,12,13)
InChIKey
LTQYSJKGRPGMPO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of MK-0354
CAS: 851776-28-8
CID: 11159621
Formula: C7H8N6
MW: 176.18
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight176.18
XLogP30.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass176.08104428
Monoisotopic Mass176.08104428
Topological Polar Surface Area83.1 Ų
Heavy Atom Count13
Formal Charge0
Complexity197
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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