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Perampanel (E2007; ER 155055-90

CAT: 0013-GTR19153659-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19153659-01Size:100 mg
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Description
Perampanel (E2007; ER 155055-90) is a selective noncompetitive AMPA-type glutamate receptor antagonist which has demonstrated anticonvulsant activity in experimental seizure models and antiepileptic activity in clinical trials.
CAS Number
380917-97-5
Field of Research
Pharmacology & Drug Discovery
Smiles
C1=CC=C (C=C1) N2C=C (C=C (C2=O) C3=CC=CC=C3C#N) C4=CC=CC=N4
Molecular Formula
C23H15N3O
Molecular Weight
349.3847
Notes
For research use only.

Chemical Information

Perampanel

Perampanel is a member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy. It has a role as an anticonvulsant and an AMPA receptor antagonist. It is a nitrile, a pyridone and a member of bipyridines. It is functionally related to a benzonitrile.

CAS Number380917-97-5
PubChem CID9924495
IUPAC Name2-(2-oxo-1-phenyl-5-pyridin-2-yl-3-pyridinyl)benzonitrile
Molecular FormulaC23H15N3O
Molecular Weight349.4
XLogP3.4
Topological Polar Surface Area57
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity664
SMILES
C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4
InChI
InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H
InChIKey
PRMWGUBFXWROHD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Perampanel
CAS: 380917-97-5
CID: 9924495
Formula: C23H15N3O
MW: 349.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight349.4
XLogP33.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass349.121512110
Monoisotopic Mass349.121512110
Topological Polar Surface Area57 Ų
Heavy Atom Count27
Formal Charge0
Complexity664
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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