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Cyclovirobuxine D

CAT: 0804-HY-N0107-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0107-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR[1]. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis[2]. Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction[3].
CAS Number
860-79-7
UNSPSC
12352211
Hazard Statement
H301
Target
Akt; Apoptosis; Autophagy; mTOR
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cyclovirobuxine-d.html
Purity
99.70
Solubility
Ethanol : 13 mg/mL (ultrasonic)
Smiles
C[C@H](NC)[C@@]1([H])[C@H](O)C[C@@]2(C)[C@]3([H])CC[C@@]4([H])C(C)(C)[C@@H](NC)CC[C@]4(C5)[C@]35CC[C@@]21C
Molecular Formula
C26H46N2O
Molecular Weight
402.66
Precautions
H301
References & Citations
[1]Lu J, et al. Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells. J Pharmacol Sci. 2014;125 (1) :74-82. Epub 2014 Apr 24.|[2]Wu J, et al. Cyclovirobuxine D Inhibits Cell Proliferation and Induces Mitochondria-Mediated Apoptosis in Human Gastric Cancer Cells. Molecules. 2015 Nov 19;20 (11) :20659-68.|[3]Yu B, et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011 Sep;82 (6) :868-77.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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