Products for Research Use Only
RegisterLogin

Isavuconazonium sulfate

CAT: 0013-GTR19160160-01Size: 1 gDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19160160-01Size:1 g
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), which catalyzes the demethylation of lanosterol to yield ergosterol, an important component of the fungal cell membrane. Isavuconazonium Sulfate is a prodrug of the triazole antifungal agent isavuconazole, with broad-spectrum antifungal activity. Inhibition of CYP51 leads to a decrease in fungal ergosterol production and disrupts the synthesis of the fungal cell membrane, which decreases membrane integrity, increases cell membrane permeability and promotes the loss of essential intracellular elements. This results in fungal cell lysis and death.
CAS Number
946075-13-4
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (122.72 mM)
Smiles
N1 (nc[n+] (c1) C (C) OC (=O) N (c1c (cccn1) COC (=O) CNC) C) C[C@] ([C@@H] (C) c1scc (n1) c1ccc (cc1) C#N) (O) c1c (ccc (c1) F) F.S (=O) (=O) (O) [O-]
Molecular Formula
C35H36F2N8O9S2
Molecular Weight
814.84
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Related Products

CatalogName
GTR17857612N-sulfated heparan sulfate Antibody
GTR19246352-01Dextran sulfate, low sulfate (MW 40000)
GTR19246353-01Dextran sulfate, low sulfate (MW 5000)
GTR19246351-01Dextran sulfate, high sulfate (MW 5000)
GTR19215543-01Selumetinib sulfate
GTR19210840-01Trimethoprim sulfate
GTR19205809-01GC7 Sulfate
GTR19198206-01Astromicin Sulfate
GTR19198129-01Bedoradrine sulfate
GTR19197533-01Hexoprenaline Sulfate

Alternative Products

CatalogName
HY-100373-01Isavuconazonium (sulfate)
T3934-01Isavuconazonium sulfate
HY-100373RIsavuconazonium (sulfate) (Standard)
TRC-I893431-100MGIsavuconazonium Sulfate d3
TRC-C964260-75MG(2S,3S)-Isavuconazonium Sulfate
TRC-N137473-5MGN-Nitroso Isavuconazonium Sulfate
A24588-50Isavuconazonium sulfate (BAL8557-002) 50mg
A24588-10Isavuconazonium sulfate (BAL8557-002) 10mg
A24588-100Isavuconazonium sulfate (BAL8557-002) 100mg
A24588-5Isavuconazonium sulfate (BAL8557-002) 5mg

Popular Products