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Sertindole

CAT: 0013-GTR19157518-03Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19157518-03Size:1 g
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Description
Sertindole is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D 5-HT2A and 5-HT2C (Kds = 2.7 20 0.14 and 6 nM respectively) (In Vitro) :Sertindole (0-100 μM; 48 h) attenuates proliferation of breast cancer cells.Sertindole (0.8-27.6 μM; 48 h) inhibits proliferation toward many cancers in vitro.Sertindole (5 μΜ and 10 μΜ; 24 h) attenuates migration of breast cancer cells. (In Vivo) :Sertindole (oral gavage; 10 mg/kg; once daily; 12 d) shows anti-tumor activity in vivo.
CAS Number
106516-24-9
Product Name Alternative
Lu 23-174
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:50 mg/mL (113.39 mM)
Smiles
Fc1ccc (cc1) -n1cc (C2CCN (CCN3CCNC3=O) CC2) c2cc (Cl) ccc12
Molecular Formula
C24H26ClFN4O
Molecular Weight
440.94
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-[2-[4-[5-chloro-1- (4-fluorophenyl) indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one

Chemical Information

Sertindole

Sertindole is a phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-oxoimidazolidin-1-yl)ethyl group. It has a role as an alpha-adrenergic antagonist, a H1-receptor antagonist, a serotonergic antagonist and a second generation antipsychotic. It is an organochlorine compound, an organofluorine compound, a phenylindole, a heteroarylpiperidine and an imidazolidinone.

CAS Number106516-24-9
PubChem CID60149
IUPAC Name1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one
Molecular FormulaC24H26ClFN4O
Molecular Weight440.9
XLogP4.1
Topological Polar Surface Area40.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity623
SMILES
C1CN(CCC1C2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F)CCN5CCNC5=O
InChI
InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)
InChIKey
GZKLJWGUPQBVJQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Sertindole
CAS: 106516-24-9
CID: 60149
Formula: C24H26ClFN4O
MW: 440.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight440.9
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass440.1779173
Monoisotopic Mass440.1779173
Topological Polar Surface Area40.5 Ų
Heavy Atom Count31
Formal Charge0
Complexity623
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
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