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CL2A-SN-38

CAT: 0013-GTR19157061-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157061-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC) . CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a nonclaevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond.
CAS Number
1279680-68-0
Purity
>98% (HPLC)
Solubility
DMSO : 100 mg/mL (67.54 mM; Need ultrasonic)
Smiles
O=C (O[C@] (C1=C (CO2) C (N3CC4=C (CC) C5=CC (O) =CC=C5N=C4C3=C1) =O) (CC) C2=O) OCC6=CC=C (NC ([C@H] (CCCCN) NC (COCC (NCCOCCOCCOCCOCCOCCOCCOCCOCCN7N=NC (CNC (C8CCC (CN9C (C=CC9=O) =O) CC8) =O) =C7) =O) =O) =O) C=C6
Molecular Formula
C??H??N??O??
Molecular Weight
1480.61
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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