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DS-6051b

CAT: 0013-GTR19156914-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156914-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DS-6051b is a new-generation selective inhibitor of ROS1/NTRK including ROS1, NTRK1, NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively.DS-6051b inhibited the growth of the ROS1 fusion-positive HCC78 cancer cell line and the CD74-ROS1 overexpressed Ba/F3 cells. DS-6051b potently inhibited autophosphorylation of ROS1 in the SLC34A2-ROS1 harboring HCC78 cells and CD74-ROS1-expressed Ba/F3 cells at approximately single-digit to double-digit nanomolar concentration.DS-6051b induced tumor shrinkage at a ≥50mg/kg in vivo experiments using the KM12-bearing mouse xenograft model or higher treatment dose without significant body weight loss.
CAS Number
1505515-69-4
Product Name Alternative
Taletrectinib, AB-106
Purity
>98% (HPLC)
Solubility
DMSO:50 mg/ml (90.64 mM)
Smiles
OC (=O) CCCCC (O) =O.C[C@@H] (N) COc1ccc (cc1) -c1cnc2ccc (N[C@H] (C) c3cccc (F) c3) nn12
Molecular Formula
C29H34FN5O5
Molecular Weight
551.61
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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