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Mofezolac

CAT: 0013-GTR19158147-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19158147-02Size:500 mg
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Description
Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000. (In Vitro) :Mofezolac inhibits platelet aggregation with an IC50 of 0.45 μM in human platelet rich plasma (hPRP) assay.Mofezolac slightly increase Bortezomib cytotoxic effect on multiple myeloma (MM) cell lines (NCI-H929 and RPMI-8226) and affects MM cell cycle and apoptosis when co-administered with the proteasome inhibitor Bortezomib. (In Vivo) :Mofezolac (1-30 mg/kg; oral administration; once) treatment results in the suppression of writhing induced by the intraperitoneal injection of phenyl-p-benzoquinone in mice.
CAS Number
78967-07-4
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:10 mM; Water:Insoluble; Ethanol:Insoluble
Smiles
COc1ccc (cc1) -c1noc (CC (O) =O) c1-c1ccc (OC) cc1
Molecular Formula
C19H17NO5
Molecular Weight
339.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (34-bis (4-methoxyphenyl) isoxazol-5-yl) acetic acid

Chemical Information

Mofezolac

Mofezolac (TN) is a member of methoxybenzenes.

CAS Number78967-07-4
PubChem CID4237
IUPAC Name2-[3,4-bis(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid
Molecular FormulaC19H17NO5
Molecular Weight339.3
XLogP3.1
Topological Polar Surface Area81.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count25
Formal Charge0
Complexity430
SMILES
COC1=CC=C(C=C1)C2=C(ON=C2C3=CC=C(C=C3)OC)CC(=O)O
InChI
InChI=1S/C19H17NO5/c1-23-14-7-3-12(4-8-14)18-16(11-17(21)22)25-20-19(18)13-5-9-15(24-2)10-6-13/h3-10H,11H2,1-2H3,(H,21,22)
InChIKey
DJEIHHYCDCTAAH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mofezolac
CAS: 78967-07-4
CID: 4237
Formula: C19H17NO5
MW: 339.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight339.3
XLogP33.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass339.11067264
Monoisotopic Mass339.11067264
Topological Polar Surface Area81.8 Ų
Heavy Atom Count25
Formal Charge0
Complexity430
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA5923-5Mofezolac
A22681-5Mofezolac 5mg
A22681-100Mofezolac 100mg
A22681-10Mofezolac 10mg
A22681-200Mofezolac 200mg
A22681-50Mofezolac 50mg
A22681-25Mofezolac 25mg
A22681-10mM-DMofezolac 10mM * 1mL in DMSO

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