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Mofezolac

CAT: 0013-GTR19158147-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19158147-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000. (In Vitro) :Mofezolac inhibits platelet aggregation with an IC50 of 0.45 μM in human platelet rich plasma (hPRP) assay.Mofezolac slightly increase Bortezomib cytotoxic effect on multiple myeloma (MM) cell lines (NCI-H929 and RPMI-8226) and affects MM cell cycle and apoptosis when co-administered with the proteasome inhibitor Bortezomib. (In Vivo) :Mofezolac (1-30 mg/kg; oral administration; once) treatment results in the suppression of writhing induced by the intraperitoneal injection of phenyl-p-benzoquinone in mice.
CAS Number
78967-07-4
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:10 mM; Water:Insoluble; Ethanol:Insoluble
Smiles
COc1ccc (cc1) -c1noc (CC (O) =O) c1-c1ccc (OC) cc1
Molecular Formula
C19H17NO5
Molecular Weight
339.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (34-bis (4-methoxyphenyl) isoxazol-5-yl) acetic acid

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BA5923-5Mofezolac
A22681-5Mofezolac 5mg
A22681-200Mofezolac 200mg
A22681-50Mofezolac 50mg
A22681-25Mofezolac 25mg
A22681-100Mofezolac 100mg
A22681-10Mofezolac 10mg
A22681-10mM-DMofezolac 10mM * 1mL in DMSO

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