CHS-828

CAT: 0804-HY-10079-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10079-01Size:5 mg
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Description
CHS-828 (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. CHS-828 (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity[1].
CAS Number
[200484-11-3]
Product Name Alternative
GMX1778
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; NAMPT
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GMX1778.html
Purity
99.28
Solubility
DMSO : ≥ 39 mg/mL
Smiles
N#CN/C(NCCCCCCOC1=CC=C(C=C1)Cl)=N\C2=CC=NC=C2
Molecular Formula
C19H22ClN5O
Molecular Weight
371.86
Precautions
H302, H315, H319, H335
References & Citations
[1]Watson M, et al. The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol. 2009 Nov;29 (21) :5872-88.|[2]Cerna D, et al. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS) -mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1) -dependent manner. J Biol Chem. 2012 Jun 22;287 (26) :22408-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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