GsMTx4

GsMTx4

• CAS Number: 1209500-46-8
• UNSPSC Description: GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology[1][2][4].
• Target Antigen: Piezo Channel; TRP Channel
• Type: Peptides
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/gsmtx4.html
• Purity: 99.80
• Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
• Smiles: O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H]2CCCCN)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H](CCCCN)C(N[C@H]%10CC(C)C)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](CC(N)=O)C(N%11[C@@H](CCC%11)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H]3CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CC%12=CC=CC=C%12)C(N[C@@H](CO)C(N[C@@H](CC%13=CC=CC=C%13)C(N)=O)=O)=O)=O)=O)NC%10=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
• Molecular Weight: 4095.84
• References & Citations: [1]Gnanasambandam R, et al. GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels. Biophys J. 2017 Jan 10;112(1):31-45. |[2]T M Suchyna, et al. Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol. 2000 May;115(5):583-98. |[3]Anna Acheva, et al. Adipokine Leptin Co-operates With Mechanosensitive Ca 2 +-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells. Front Cell Dev Biol. 2021 Jan 6;8:607038. |[4]María Velasco-Estevez, et al. Inhibition of Piezo1 attenuates demyelination in the central nervous system. Glia. 2020 Feb;68(2):356-375. |[5]Medha M Pathak, et al. Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16148-53.|[6]Seung Pyo Park, et al. A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain. Pain. 2008 Jul;137(1):208-217. Adv Sci (Weinh). 2024 Jan 15:e2309133.|Adv Sci (Weinh). 2024 Sep 11:e2409081.|Am J Physiol Cell Physiol. 2022 Aug 15.|Arch Oral Biol. 2023 Nov, 155, 105798.|Arthritis Res Ther. 2023 Jul 7;25(1):117.|Biochem Biophys Res Commun. 2022.|Biology (Basel). 2024 May 19;13(5):357.|bioRxiv. 2023 Jan 13.|bioRxiv. 2023 Oct 9.|biorxiv. 2024 Jun 03.|bioRxiv. 2024 May 8:2024.05.07.592424.|bioRxiv. 2024 November 26.|bioRxiv. 2024 September 22.|Cell Biosci. 2023 Jan 12;13(1):7.|Cell Discov. 2022 Sep 6;8(1):84.|Cell Prolif. 2024 Mar 31:e13640. |Cell. 2024 Jun 20;187(13):3409-3426.e24.|Clin Transl Med. 2023 Nov;13(11):e1481.|CNS Neurosci Ther. 2024 Sep;30(9):e14872.|FASEB J. 2022 Aug;36(8):e22423.|Genes Dis. 2024 Sep 15.|Hypertension. 2021 Sep;78(3):647-660.|Int J Mol Sci. 2023 Feb 16;24(4):4022.|Invest Ophthalmol Vis Sci. 2023 Jun 1;64(7):1.|J Cell Mol Med. 2024 Jun;28(11):e18472.|J Orthop Translat. 2024 Aug 13:48:146-155.|J Transl Med. 2023 Oct 10;21(1):711.|Mater Today Bio. 2023 Oct, 22, 100735.|Materials Today Advances. 2023, 17: 100325.|Mech Ageing Dev. 2023 Oct 13:216:111880.|Nat Commun. 2024 Aug 27.|Neuron. 2022 Nov 8;S0896-6273(22)00954-0.|Parasit Vectors. 2024 Feb 1;17(1):46.|Preprints. 2024 Apr 17.|Redox Biol. 2024 Sep 7:76:103346.|Research Square Preprint. 2024 Apr 5.|Research Square Print. December 8th, 2022.|Sci Adv. 2024 Oct 25;10(43):eadp4726.|Am J Physiol Lung Cell Mol Physiol. 2022 May 1;322(5):L737-L760.|Biomed Pharmacother. 2024 Jul:176:116837.|Int Immunopharmacol. 2024 Jul 14:139:112664.|J Gastroenterol Hepatol. 2021 Jun 24.|J Neurochem. 2021 Nov 10.|J Orthop Res. 2023 Feb 1.|Neuropharmacology. 2024 Mar 13:109896.|Research (Wash D C). 2023 Jan 20.|Stem Cells Int. 29 Jul 2022.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported