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Colesevelam (hydrochloride)

CAT: 0804-HY-106539-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106539-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Colesevelam (hydrochloride) is a bile acid sequestrant that bind bile acids in the gut. Colesevelam (hydrochloride) inhibits bile acid reabsorption, leading to increased bile acid synthesis and reduced cholesterol levels in patients with cholestatic pruritus and Crohn’s disease.
CAS Number
182815-44-7
UNSPSC
12352211
Hazard Statement
H315-H319-H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/colesevelam-hydrochloride.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
[Colesevelam(hydrochloride)]
Molecular Formula
(C3H8NCl) 2. (C9H20N2OCl2) . (C13H28NCl) 7. (C12H28N2Cl2) 6
Molecular Weight
3694.64
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Potthoff MJ, Potts A, He T, et al. Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Am J Physiol Gastrointest Liver Physiol. 2013;304 (4) :G371-G380. |[2]Cabré N, Duan Y, Llorente C, et al. Colesevelam Reduces Ethanol-Induced Liver Steatosis in Humanized Gnotobiotic Mice. Cells. 2021;10 (6) :1496.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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Alternative Products

CatalogName
MBS3616612-01Colesevelam Hydrochloride
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RM-C152202-01Colesevelam Impurity 2
RM-C152203-01Colesevelam Impurity 3
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RM-C152208-01Colesevelam Impurity 8
AR-C03468-01Colesevelam Hydroxyquat Impurity
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AR-C03469-01Colesevelam Methoxyquat Impurity
RM-C152207-01Colesevelam Impurity 7

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