[Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA)

[Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA)

• UNSPSC Description: [Ala1,3,11,15]-Endothelin (53-63) (TFA) is an ETB agonist. [Ala1,3,11,15]-Endothelin (53-63) (TFA) has selectivity for ETB with IC50 values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) (TFA) can be used for the research of vasoconstriction[1].
• Target Antigen: Endothelin Receptor
• Type: Peptides
• Related Pathways: GPCR/G Protein
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Cardiovascular Disease; Endocrinology
• Assay Protocol: https://www.medchemexpress.com/ala1-3-11-15-endothelin-tfa.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](C)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N.OC(C(F)(F)F)=O
• Molecular Weight: 2481.70
• References & Citations: [1]Nakamichi K, et al. Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala1,3,11,15]ET-1. Biochem Biophys Res Commun. 1992 Jan 15;182(1):144-50.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported