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Broussonin E

CAT: 0804-HY-N2963-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N2963-01Size:5 mg
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Description
Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis[1].
CAS Number
[90902-21-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Arginase; COX; ERK; Interleukin Related; JAK; p38 MAPK; STAT; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/broussonin-e.html
Purity
98.11
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC(OC)=CC=C1CCCC2=CC=C(OC)C(O)=C2
Molecular Formula
C17H20O4
Molecular Weight
288.34
Precautions
H315, H319, H335
References & Citations
[1]Huang SP, et al. Broussonin E suppresses LPS-induced inflammatory response in macrophages via inhibiting MAPK pathway and enhancing JAK2-STAT3 pathway. Chin J Nat Med. 2019 May 20;17 (5) :372-380.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2; ERK; IL-1; IL-10; IL-6; JAK2; p38 MAPK; STAT3

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