Broussonin E

• Description :

  Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis[1].

• CAS Number :

  [90902-21-9]

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Arginase; COX; ERK; Interleukin Related; JAK; p38 MAPK; STAT; TNF Receptor

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/broussonin-e.html

• Purity :

  98.11

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC1=CC(OC)=CC=C1CCCC2=CC=C(OC)C(O)=C2

• Molecular Formula :

  C17H20O4

• Molecular Weight :

  288.34

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Huang SP, et al. Broussonin E suppresses LPS-induced inflammatory response in macrophages via inhibiting MAPK pathway and enhancing JAK2-STAT3 pathway. Chin J Nat Med. 2019 May 20;17 (5) :372-380.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  COX-2; ERK; IL-1; IL-10; IL-6; JAK2; p38 MAPK; STAT3