CYPMPO

• Description:

  CYPMPO is a spin-trapping reagent. CYPMPO, a cyclic DEPMPO-type nitrone, is evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. anti-oxidant and anti-tumor activity[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335, H402

• Target:

  Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cypmpo.html

• Purity:

  99.00

• Solubility:

  DMSO : 20 mg/mL (ultrasonic; warming)

• Smiles:

  CC1(P2(OCC(C)(C)CO2)=O)[N+]([O-])=CCC1

• Molecular Formula:

  C10H18NO4P

• Molecular Weight:

  247.23

• Precautions:

  H315, H319, H335, H402

• References & Citations:

  [1]Masato Kamibayashi, et al. Synthesis and characterization of a practically better DEPMPO-type spin trap, 5- (2,2-dimethyl-1,3-propoxy cyclophosphoryl) -5-methyl-1-pyrroline N-oxide (CYPMPO) . Free Radic Res. 2006 Nov;40 (11) :1166-72. |[2]Ryohei Umeda, et al. Direct free radical scavenging effects of water-soluble HMG-CoA reductase inhibitors. J Clin Biochem Nutr. 2019 Jan;64 (1) :20-26. |[3]Matsuzaki S, et al. Identification of mitochondrial electron transport chain-mediated NADH radical formation by EPR spin-trapping techniques. Biochemistry 2011, 50, 50, 10792-10803.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [934182-09-9]