CyPPA

CAT: 0804-HY-W011509-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W011509-01Size:5 mg
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Description
CyPPA is a positive modulator of hSK3 and hSK2, with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels[1][2].
CAS Number
[73029-73-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cyppa.html
Concentration
10mM
Purity
99.71
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC(NC2CCCCC2)=NC(N3N=C(C)C=C3C)=N1
Molecular Formula
C16H23N5
Molecular Weight
285.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Br J Pharmacol. 2007 Jul;151 (5) :655-65.|[2]Dana V Skarra, et al. CyPPA, a positive modulator of small-conductance Ca (2+) -activated K (+) channels, inhibits phasic uterine contractions and delays preterm birth in mice. Am J Physiol Cell Physiol. 2011 Nov;301 (5) :C1027-35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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