VAS 3947

• Description:

  VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins[1][2].

• UNSPSC:

  12352005

• Target:

  Apoptosis; NADPH Oxidase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/vas-3947.html

• Concentration:

  10mM

• Purity:

  99.59

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  C12=NC=NC (SC3=NC=CO3) =C1N=NN2CC4=CC=CC=C4

• Molecular Formula:

  C14H10N6OS

• Molecular Weight:

  310.33

• References & Citations:

  [1]Wind S, et al. Comparative pharmacology of chemically distinct NADPH oxidase inhibitors. Br J Pharmacol. 2010;161 (4) :885-898. |[2]El Dor M, et al. VAS3947 Induces UPR-Mediated Apoptosis through Cysteine Thiol Alkylation in AML Cell Lines. Int J Mol Sci. 2020;21 (15) :5470. Published 2020 Jul 31. |[3]Lu WJ, et al. VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC. Sci Rep. 2019;9 (1) :18852. Published 2019 Dec 11.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  869853-70-3