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DiFMUP

CAT: 0804-HY-120166-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120166-01Size:5 mg
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Description
DiFMUP is a fluorogenic substrate, and has been widely used for the continuous detection of phosphatase activities. DiFMUP is hydrolysis by a phosphatase results in the release of Xuorescent DIFMU, which can be easily followed in continuous mode by a Xuorescence reader[1][2].
CAS Number
214491-43-7
Product Name Alternative
6,8-Difluoro-4-methylumbelliferyl phosphate
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/difmup.html
Purity
99.05
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=P(OC1=C(C(OC2=O)=C(C(C)=C2)C=C1F)F)(O)O
Molecular Formula
C10H7F2O6P
Molecular Weight
292.13
References & Citations
[1]Gee KR, et, al. Fluorogenic substrates based on fluorinated umbelliferones for continuous assays of phosphatases and beta-galactosidases. Anal Biochem. 1999 Aug 15;273 (1) :41-8.|[2]Welte S, et, al. 6,8-Difluoro-4-methylumbiliferyl phosphate: a fluorogenic substrate for protein tyrosine phosphatases. Anal Biochem. 2005 Mar 1;338 (1) :32-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

6,8-Difluoro-4-methylumbelliferyl phosphate

6,8-difluoro-4-methylumbelliferyl phosphate is a member of coumarins. It is functionally related to a coumarin. It is a conjugate acid of a 6,8-difluoro-4-methylumbelliferyl phosphate (2-).

CAS Number214491-43-7
PubChem CID2786976
IUPAC Name(6,8-difluoro-4-methyl-2-oxochromen-7-yl) dihydrogen phosphate
Molecular FormulaC10H7F2O6P
Molecular Weight292.13
XLogP0.4
Topological Polar Surface Area93.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count2
Heavy Atom Count19
Formal Charge0
Complexity461
SMILES
CC1=CC(=O)OC2=C(C(=C(C=C12)F)OP(=O)(O)O)F
InChI
InChI=1S/C10H7F2O6P/c1-4-2-7(13)17-9-5(4)3-6(11)10(8(9)12)18-19(14,15)16/h2-3H,1H3,(H2,14,15,16)
InChIKey
DZANYXOTJVLAEE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6,8-Difluoro-4-methylumbelliferyl phosphate
CAS: 214491-43-7
CID: 2786976
Formula: C10H7F2O6P
MW: 292.13
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight292.13
XLogP30.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count2
Exact Mass291.99483126
Monoisotopic Mass291.99483126
Topological Polar Surface Area93.1 Ų
Heavy Atom Count19
Formal Charge0
Complexity461
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA8085-25DiFMUP
79769SHP-2 Substrate (DiFMUP)

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