Recombinant Human HER3 Protein

CAT: 0013-GTR19124794-01Size: 10 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR19124794-01Size:10 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Recombinant Human Receptor Tyrosine-Protein Kinase ErbB-3 is produced by our Mammalian expression system and the target gene encoding Ser20-Thr643 is expressed with a mouse IgG1 Fc tag at the C-terminus.

Product Name Alternative

Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; ERBB3; HER3

UniProt

P21860

Expression Region

Ser20-Thr643

Conjugation

Unconjugated

Tag

C-mFc

Origin

Human

Field of Research

Signal Transduction

Endotoxin

< 1 EU/μg as determined by LAL test.

Purity

SDS-PAGE: Greater than 95% as determined by reducing SDS-PAGE.

Bioactivity

BLI: Loaded Human NRG1Beta (245AA) (Cat#orb3002365) on APS Biosensor, can bind Human HER3-mFc (Cat#orb2993801) with an affinity constant of 3.6 nM as determined in BLI assay. Loaded Human NRG1Beta (246AA) (Cat#CH84) on APS Biosensor, can bind Human HER3-mFc (Cat#orb2993801) with an affinity constant of 4.3 nM as determined in BLI assay.

Form

Lyophilized

Molecular Weight

Predicted: 95.1 KDa. Observed: 120-135 KDa, reducing conditions

Storage Conditions

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Notes

For research use only.

Preservative

0.2 μm filtered solution of PBS, pH 7.4.

UniProtKB · P21860

Receptor tyrosine-protein kinase erbB-3

ERBB3_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P21860
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ERBB3
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.7.10.1
Processing: Precursor
Secondary accessions: A8K6L6, B4DIK7, B4DV32, E9PDT8, Q9BUD7

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneMembraneSecreted

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

KinaseReceptorTransferaseTyrosine-protein kinase

Domain

SignalTransmembraneTransmembrane helix

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