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UNC6852

CAT: 0804-HY-130708-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-130708-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC50 of 247 nM for EED[1].
CAS Number
2688842-08-0
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Histone Methyltransferase; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc6852.html
Purity
98.49
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C=C1)C2=CN=C(N3C2=NN=C3)NCC4=CC=CO4)NCCCC(N[C@H](C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)=O)C(C)(C)C)=O
Molecular Formula
C43H48N10O6S
Molecular Weight
832.97
Precautions
H315, H319, H320
References & Citations
[1]Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27 (1) :47-56.e15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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