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Drisapersen (sodium)

CAT: 0804-HY-145724A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145724A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Drisapersen sodium, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.
CAS Number
1181666-20-5
Product Name Alternative
Kyndrisa (sodium) ; GSK2402968A (sodium) ; PRO051 (sodium)
UNSPSC
12352208
Target
Others
Type
Oligonucleotides
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/drisapersen-sodium.html
Purity
98.61
Solubility
10 mM in H2O
Smiles
[Drisapersen(sodium)]
Molecular Formula
C211H256N76Na19O119P19S19
Molecular Weight
6978 (free acid)
References & Citations
[1]Flanigan KM, Voit T, Rosales XQ, et al. Pharmacokinetics and safety of single doses of drisapersen in non-ambulant subjects with Duchenne muscular dystrophy: results of a double-blind randomized clinical trial. Neuromuscul Disord. 2014;24 (1) :16-24. |[2]Voit T, Topaloglu H, Straub V, et al. Safety and efficacy of drisapersen for the treatment of Duchenne muscular dystrophy (DEMAND II) : an exploratory, randomised, placebo-controlled phase 2 study. Lancet Neurol. 2014;13 (10) :987-996.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3

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