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Diphylline

CAT: 0804-HY-B0128-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0128-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema[1][2].
CAS Number
479-18-5
Product Name Alternative
Diprophylline
UNSPSC
12352005
Hazard Statement
H302
Target
Adenosine Receptor; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Diphylline.html
Purity
99.25
Solubility
DMSO : ≥ 50 mg/mL|H2O : 20 mg/mL (ultrasonic)
Smiles
O=C(N1C)N(C)C2=C(N(CC(O)CO)C=N2)C1=O
Molecular Formula
C10H14N4O4
Molecular Weight
254.25
Precautions
H302
References & Citations
[1]Schwabe U, et al. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330 (3) :212-21.|[2]Yosry El-said, et al. In-vitro evaluation of sustained-release dyphylline tablets. Drug Development and Industrial Pharmacy. Volume 17, 1991 - Issue 2
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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