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Curcumol

CAT: 0804-HY-N0104-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0104-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Curcumol ((-) -Curcumol), a bioactive sesquiterpenoid, possesses numerous pharmacological activities like anticancer, antimicrobial, antifungal, antiviral, and antiinflammatory. Curcumol is a potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers[1].
CAS Number
4871-97-0
Product Name Alternative
(-) -Curcumol
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Curcumol.html
Concentration
10mM
Purity
99.50
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O[C@@]1(C2)[C@H](C(C)C)C[C@]3(O1)[C@@H](C)CC[C@@]3([H])C2=C
Molecular Formula
C15H24O2
Molecular Weight
236.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Wei W, et al. Curcumol: From Plant Roots to Cancer Roots. Int J Biol Sci. 2019;15 (8) :1600-1609. Published 2019 Jun 4.|[2]Zhang J, et al. Curcumol Exerts Anticancer Effect in Cholangiocarcinoma Cells via Down-Regulating CDKL3. Front Physiol. 2018;9:234. Published 2018 Mar 20.|[3]Wang J, et al. Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway. J Ethnopharmacol. 2018;210:1-9.|[4]Ning L, et al. Curcumol Suppresses Breast Cancer Cell Metastasis by Inhibiting MMP-9 Via JNK1/2 and Akt-Dependent NF-κB Signaling Pathways. Integr Cancer Ther. 2016;15 (2) :216-225.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 3

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300128Curcumol
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