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Hydromorphone Hydrochloride

CAT: 1299-RM-H250500-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:1299-RM-H250500-01Size:10 mg
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CAS Number
71-68-1
Synonyms
(4R,4aR,7aR,12bS) -9-hydroxy-3-methyl-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7 (7aH) -one hydrochloride
Molecular Formula
C17H20ClNO3
Molecular Weight
321.8
Target Alternative Name
Hydromorphone
Product Name Synonym
(4R,4aR,7aR,12bS) -9-hydroxy-3-methyl-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7 (7aH) -one hydrochloride

Chemical Information

Hydromorphone Hydrochloride

Hydromorphone Hydrochloride is the hydrochloride salt form of hydromorphone, the hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.

CAS Number71-68-1
PubChem CID5462347
IUPAC Name(4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrochloride
Molecular FormulaC17H20ClNO3
Molecular Weight321.8
Topological Polar Surface Area49.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Heavy Atom Count22
Formal Charge0
Complexity494
SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4.Cl
InChI
InChI=1S/C17H19NO3.ClH/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;/h2,4,10-11,16,19H,3,5-8H2,1H3;1H/t10-,11+,16-,17-;/m0./s1
InChIKey
XHILEZUETWRSHC-NRGUFEMZSA-N
Chemical Structure
2D Structure
2D structure of Hydromorphone Hydrochloride
CAS: 71-68-1
CID: 5462347
Formula: C17H20ClNO3
MW: 321.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight321.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Exact Mass321.1131712
Monoisotopic Mass321.1131712
Topological Polar Surface Area49.8 Ų
Heavy Atom Count22
Formal Charge0
Complexity494
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
CS-EK-01793Hydromorphone hydrochloride
TRC-H714652-25MGHydromorphone-d3 Hydrochloride
TRC-H714685-50MGHydromorphone N-Oxide Hydrochloride
TRC-H714653-10MGHydromorphone-13C,d3 Hydrochloride
TRC-KIT2395-1X1MLHydromorphone Hydrochloride (1mg/ml in Methanol)
TRC-KIT4885-5X1MLHydromorphone N-Oxide Hydrochloride (1.0mg/ml in DMSO)
TRC-KIT2397-1X1MLHydromorphone-13C,d3 Hydrochloride (1.0mg/ml in Methanol)
AR-M05406-01Hydromorphone
80-1182Hydromorphone-HRP
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