Akt1&PKA-IN-1
CAT:
804-HY-148868-04
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Akt1&PKA-IN-1
- CAS Number: 1334107-58-2
- UNSPSC Description: Akt1&PKA-IN-1 is a potent dual Akt/PKA inhibitor with IC50 values of 0.03 , 0.11 μM, and 9.8 μM for PKAa, Akt, and CDK2, respectively. Akt1&PKA-IN-1 is selective for cyclin-dependent kinase 2 (CDK2)[1].
- Target Antigen: Akt; CDK; PKA
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;PI3K/Akt/mTOR;Stem Cell/Wnt;TGF-beta/Smad
- Applications: Cancer-Kinase/protease
- Field of Research: Others
- Assay Protocol: https://www.medchemexpress.com/akt1-pka-in-1.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(C1=CC2=C(C=NC=C2)C=C1)N[C@@H](C3CNC3)C4=CC(Cl)=C(C=C4)Cl
- Molecular Weight: 386.27
- References & Citations: [1]Ashton KS, et al. Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5191-6.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported