Foretinib

• Description:

  Foretinib is a multi-target tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR.

• Product Name Alternative:

  XL880; GSK1363089; GSK089; EXEL-2880

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  C-Met/HGFR; VEGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Foretinib.html

• Concentration:

  10mM

• Purity:

  99.59

• Solubility:

  DMSO : 75 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=CC=C(C(F)=C1)OC2=C3C=C(C(OCCCN4CCOCC4)=CC3=NC=C2)OC)C5(CC5)C(NC6=CC=C(C=C6)F)=O

• Molecular Formula:

  C34H34F2N4O6

• Molecular Weight:

  632.65

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Qian F, et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res, 2009, 69 (20), 8009-8016.|[2]Kataoka Y, et al. Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks. Invest New Drugs, 2011.|[3]Eder JP, et al. A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2. Clin Cancer Res, 2010, 16 (13), 3507-3516.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  VEGFR1/Flt-1; VEGFR2/KDR/Flk-1

• CAS Number:

  [849217-64-7]