Linarin

CAT: 0804-HY-N0528-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0528-01Size:5 mg
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Description
Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE) . Linarin has many activities, such as anti-inflammatory, antioxidant, sleep aid and sedation, bone differentiation, anti-tumor, antibacterial and antiviral. Linarin can be used to study diseases such as the nervous system, osteoporosis and cancer[1][2][3][4].
CAS Number
[480-36-4]
Product Name Alternative
Buddleoside; Linarine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bacterial; Cholinesterase (ChE) ; HIV; Influenza Virus; PKA; TNF Receptor
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Neuronal Signaling; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/linarin.html
Purity
98.02
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C=C(C1=CC=C(OC)C=C1)OC2=CC(O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO[C@H](O[C@@H](C)[C@H](O)[C@H]4O)[C@@H]4O)=C5)C2=C5O
Molecular Formula
C28H32O14
Molecular Weight
592.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Päivi P. Oinonen, etc. Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensis, Fitoterapia, Volume 77, Issue 6, 2006, Pages 429-434, ISSN 0367-326X|[2]Mottaghipisheh J, et al. Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review. Pharmaceuticals (Basel) . 2021 Oct 29;14 (11) :1104.|[3]Singh RP, et al. Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. Carcinogenesis. 2005 Apr;26 (4) :845-54.|[4]Li J, et al. Linarin promotes osteogenic differentiation by activating the BMP-2/RUNX2 pathway via protein kinase A signaling. Int J Mol Med. 2016 Apr;37 (4) :901-10.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE

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