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Manogepix

CAT: 0804-HY-18233-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18233-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Manogepix (E1210) is a first-in-class, broad-spectrum and orally active antifungal. Manogepix has a mechanism of action-inhibition of fungal glycosylphosphatidylinositol (GPI) biosynthesis[1][2].
CAS Number
936339-60-5
Product Name Alternative
E1210; APX001A
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/manogepix.html
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC=CC=C1C2=CC(CC3=CC=C(COC4=NC=CC=C4)C=C3)=NO2
Molecular Formula
C21H18N4O2
Molecular Weight
358.39
Precautions
H315, H319, H320
References & Citations
[1]Watanabe NA, et al. E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis. Antimicrob Agents Chemother. 2012 Feb;56 (2) :960-71.|[2]Hata K, et al. Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis. Antimicrob Agents Chemother. 2011 Oct;55 (10) :4543-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Alternative Products

CatalogName
C07209-25mgManogepix (E1210)

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