Astaxanthin

• Description:

  Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed[1][2][3][4][5].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; NF-κB; PPAR; Reactive Oxygen Species (ROS) ; STAT

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Metabolic Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Astaxanthin.html

• Purity:

  98.0

• Solubility:

  DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : Acetone mixture (1:1) : 2 mg/mL (ultrasonic; warming; heat to 60°C) |THF : 5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CC(/C=C/C(C(C)(C[C@H](O)C1=O)C)=C1C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C(C(C)(C[C@H](O)C2=O)C)=C2C

• Molecular Formula:

  C40H52O4

• Molecular Weight:

  596.84

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Sun SQ, et al. Anti-Tumor Effects of Astaxanthin by Inhibition of the Expression of STAT3 in Prostate Cancer. Mar Drugs. 2020 Aug 7;18 (8) :415. |[2]Fu D, et al. Effect of astaxanthin on retinal pigment epithelial cells in high glucose: an in-vitro study. Biomed Res, 2017, 28 (15) : 6839-6843. |[3]Zhang X, et al. Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARγ) in K562 cancer cells. Arch Biochem Biophys. 2011 Aug 1;512 (1) :96-106. |[4]Gross GJ, et al. Seven day oral supplementation with Cardax (disodium disuccinate astaxanthin) provides significant cardioprotection and reduces oxidative stress in rats. Mol Cell Biochem. 2006 Feb;283 (1-2) :23-30. |[5]Zhang L, et al. Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin. Mar Drugs. 2015 Jul 14;13 (7) :4310-30.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  PPARγ; STAT3

• CAS Number:

  [472-61-7]