Recombinant Mouse CDNF protein

• Background:

  Cerebral dopamine neurotrophic factor (CDNF), also known as ARMET-like protein 1, is encoded by the CDNF gene and widely expressed in neuronal and non-neuronal tissues. The CDNF is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). Furthermore, it also prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. By research, CDNF might be beneficial for the treatment of Parkinsons disease. Recombinant Mouse CDNF contains 163 amino acid residues and it shares 81 % and 87 % a.a. sequence identity with human and rat CDNF.

• Molecular Weight:

  Approximately 18.5 kDa, a single non-glycosylated polypeptide chain containing 163 amino acids.

• CAS Number:

  9000-83-3