Recombinant Mouse FGF-21 protein

Recombinant Mouse FGF-21 protein

• Background: Fibroblast growth factor-21 (FGF-21) belongs to the large FGF family and it is specifically induced by HMGCS2 activity. In mice, brown adipose tissue becomes a source of systemic FGF21 after cold exposure. FGF-21 stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression) and the activity depends on the presence of KLB. FGF-21, in the presence of betaKlotho as a protein cofactor, signals through the FGFR 1c and 4 receptors. Recombinant Mouse FGF-21 contains 182 amino acids residues and show limited binding to heparin. In addition, Mouse FGF-21 respectively shows 81 % and 92 % a.a. identity to human and rat FGF-21, and it show activity on human and rat cells.
• CAS Number: 9000-83-3
• Reconstitution: Lyophilized from a .2 μm filtered concentrated solution in 2 mM Tris, 5 mM NaCl, pH 8.5.
• Molecular Weight: Approximately 19.9 kDa, a single non-glycosylated polypeptide chain containing 182 amino acids.