Recombinant Mouse G-CSF protein

Recombinant Mouse G-CSF protein

• Background: Granulocyte Colony Stimulating Factor (G-CSF) is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation, and activation of hematopoietic cells of the neutrophilic granulocyte lineage. It is produced mainly by monocytes and macrophages upon activation by endotoxin, TNFα and IFN-γ. Other cell types including fibroblasts, endothelial cells, astrocytes and bone marrow stromal cells can also secrete G-CSF after LPS, IL1 or TNF-α activation. In addition, various carcinoma cell lines and myeloblastic leukemia cells can express G-CSF constitutively.
• CAS Number: 9000-83-3
• Reconstitution: Lyophilized from a .2 μm filtered solution in PBS, pH 7.4.
• Molecular Weight: Approximately 18.9 kDa, a single non-glycosylated polypeptide chain containing 178 amino acids.