Recombinant Mouse NOV protein

Recombinant Mouse NOV protein

• Background: NOV is a member of the CCN family of secreted cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm’s tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities. Recombinant Mouse NOV is a 36.4 kDa protein containing 333 amino acid residues. It is composed of four distinct structural domains (modules) - the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).
• CAS Number: 9000-83-3
• Reconstitution: Lyophilized from a .2 μm filtered solution of PBS, pH 7.4.
• Molecular Weight: Approximately 36.4 kDa, a single non-glycosylated polypeptide chain containing 333 amino acids.