Recombinant Rhesus Macaque IL-5 protein

Recombinant Rhesus Macaque IL-5 protein

• Background: Through binding to the IL-5 receptor, IL-5 stimulates B cell growth and increases immunroglobulin secretion. It is also a key mediator in eosinophil activation. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma. IL-5 is a 115-amino acid (in rhesus macaque, 133 in the Mouse) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely IL-3 and GM-CSF), this glycoprotein in its active form is a homodimer.
• CAS Number: 9000-83-3
• Reconstitution: Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.
• Molecular Weight: Approximately 26.1 kDa, a disulfide-linked homodimer of two 115 amino acid polypeptide chains.