SR-3677

• Description :

  SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM.

• CAS Number :

  [1072959-67-1]

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Autophagy; ROCK

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/SR-3677.html

• Purity :

  99.83

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CN(C)CCOC1=C(NC(C2OC(C=CC=C3)=C3OC2)=O)C=CC(C4=CNN=C4)=C1

• Molecular Formula :

  C22H24N4O4

• Molecular Weight :

  408.45

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Feng Y, et al. Discovery of substituted 4- (pyrazol-4-yl) -phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51 (21) :6642-5.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ROCK1; ROCK2