SR-3677

• Description:

  SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Autophagy; ROCK

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/SR-3677.html

• Purity:

  99.83

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CN(C)CCOC1=C(NC(C2OC(C=CC=C3)=C3OC2)=O)C=CC(C4=CNN=C4)=C1

• Molecular Formula:

  C22H24N4O4

• Molecular Weight:

  408.45

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Feng Y, et al. Discovery of substituted 4- (pyrazol-4-yl) -phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51 (21) :6642-5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  ROCK1; ROCK2

• CAS Number:

  [1072959-67-1]