Ribociclib Succinate

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CAT#:1299-RM-R090200-01Size:10 mg

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CAS Number

1374639-75-4

Synonyms

7-cyclopentyl-N, N-dimethyl-2- ((5- (piperazin-1-yl) pyridin-2-yl) amino) -7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinic acid

Molecular Formula

C23H30N8O C4H6O4

Molecular Weight

434.54 118.09

Target Alternative Name

Ribociclib

Product Name Synonym

7-cyclopentyl-N, N-dimethyl-2- ((5- (piperazin-1-yl) pyridin-2-yl) amino) -7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinic acid

Chemical Information

Ribociclib Succinate

Ribociclib Succinate is the succinate salt form of ribociclib, an orally available inhibitor of the cyclin-dependent kinases (CDKs) 4 and 6, with antineoplastic activity. Upon oral administration, ribociclib specifically targets, binds to and inhibits CDK4 and CDK6. This inhibits the cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, which inhibits phosphorylation of the retinoblastoma (Rb) protein. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle dysregulation.

CAS Number	1374639-75-4
PubChem CID	57334219
IUPAC Name	butanedioic acid;7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
Molecular Formula	C27H36N8O5
Molecular Weight	552.6
Topological Polar Surface Area	166
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	8
Heavy Atom Count	40
Formal Charge	0
Complexity	728

SMILES

CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5.C(CC(=O)O)C(=O)O

InChI

InChI=1S/C23H30N8O.C4H6O4/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;5-3(6)1-2-4(7)8/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28);1-2H2,(H,5,6)(H,7,8)

InChIKey

NHANOMFABJQAAH-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1374639-75-4

CID: 57334219

Formula: C27H36N8O5

MW: 552.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	552.6
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	8
Exact Mass	552.28086628
Monoisotopic Mass	552.28086628
Topological Polar Surface Area	166 Å²
Heavy Atom Count	40
Formal Charge	0
Complexity	728
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
RM-R090201-01	Ribociclib D6
RM-R090228-01	Ribociclib-D8
RM-R090220-01	Ribociclib HCl
RM-R090226-01	Ribociclib Impurity 26
RM-R090225-01	Ribociclib Impurity 25
RM-R090224-01	Ribociclib Impurity 24
RM-R090217-01	Ribociclib Impurity 17
RM-R090215-01	Ribociclib Impurity 15
RM-R090209-01	Ribociclib Impurity 9
RM-R090208-01	Ribociclib Impurity 8

Alternative Products

Catalog	Name
M22128-01	Ribociclib succinate
HY-15777BR-01	Ribociclib succinate (Standard)
ZEC63979-01	Ribociclib succinate hydrate

Ribociclib Succinate

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