Isoxsuprine-d6 (hydrochloride)

Isoxsuprine-d6 (hydrochloride)

• CAS Number: 2706004-35-3
• UNSPSC Description: Isoxsuprine-d6 (hydrochloride) is the deuterium labeled Isoxsuprine hydrochloride. Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.
• Target Antigen: Adrenergic Receptor; iGluR; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling;Others
• Field of Research: Neurological Disease; Endocrinology
• Purity: 99.73
• Solubility: 10 mM in DMSO
• Smiles: OC(C(NC(C([2H])([2H])[2H])([2H])C([2H])([2H])OC1=CC=CC=C1)C)C2=CC=C(O)C=C2.[H]Cl
• Molecular Weight: 343.88
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Falkay G, et al. Affinity of tocolytic agents on human placental and myometrial beta-adrenergic receptors. J Perinat Med. 1986;14(2):109-13.|[3]Kretschy N, et al. In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br J Cancer. 2013 Feb 19;108(3):570-8.|[4]Hill JW, et al. Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PLoS One. 2014 May 7;9(5):e96761.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported