RMC-9805

Chemical Information
Zoldonrasib is an orally bioavailable covalent tri-complex inhibitor of the oncogenic KRAS substitution mutation G12D, with potential antineoplastic activity. Upon oral administration, zoldonrasib specifically targets and non-covalently binds to cyclophilin A to form a non-covalent binary complex, which subsequently covalently and irreversibly binds to the active GTP-bound form of KRAS G12D (KRASG12D(ON)). This prevents KRAS G12D-mediated signaling and activation of downstream survival pathways. This causes apoptosis in KRAS G12D-expressing tumor cells. In addition, inhibition of KRAS G12D signaling by zoldonrasib abrogates the suppressive tumor microenvironment (TME) and enhances an anti-tumor immune response which further leads to an inhibition of proliferation of KRAS G12D-expressing tumor cells. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell proliferation, invasion, and metastasis.
| CAS Number | 2922732-54-3 |
| PubChem CID | 168201327 |
| IUPAC Name | (2S)-2-cyclopentyl-2-[(5S)-2-[(2R,3R)-3-cyclopropyl-1-methylaziridine-2-carbonyl]-2,7-diazaspiro[4.4]nonan-7-yl]-N-[(6S,8S,14S)-21-[5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]-3-pyridinyl]-18,18-dimethyl-9,15-dioxo-22-(2,2,2-trifluoroethyl)-5,16-dioxa-2,10,22,28-tetrazapentacyclo[18.5.2.12,6.110,14.023,27]nonacosa-1(26),20,23(27),24-tetraen-8-yl]acetamide |
| Molecular Formula | C63H88F3N11O7 |
| Molecular Weight | 1168.4 |
| XLogP | 7.2 |
| Topological Polar Surface Area | 160 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 17 |
| Rotatable Bond Count | 12 |
| Heavy Atom Count | 84 |
| Formal Charge | 0 |
| Complexity | 2370 |
| Property | Value |
|---|---|
| Molecular Weight | 1168.4 |
| XLogP3 | 7.2 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 17 |
| Rotatable Bond Count | 12 |
| Exact Mass | 1167.68202867 |
| Monoisotopic Mass | 1167.68202867 |
| Topological Polar Surface Area | 160 Ų |
| Heavy Atom Count | 84 |
| Formal Charge | 0 |
| Complexity | 2370 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 8 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Related Products
Alternative Products
Popular Products

FNC Coating Mix®, 100 ml
SKU: 0407|Size: 100 mL

Mouse Sulfatase 2 (SULF2) ELISA Kit
SKU: RD-SULF2-Mu-01|Size: 96 Tests

POLI Polyclonal Antibody
SKU: RD89193A-01|Size: 60 μL

EvaGreen® 20X in Water, 1 mL
SKU: #31000-T|Size: 1x 1 mL

Ruxolitinib (INCB018424)
SKU: A3012-25|Size: 25 mg

Plant DNA Kit
SKU: 3201250|Size: 250 Tests

Superior Broth™
SKU: 0105|Size: 500 g

Recombinant Clostridium Perfringens recX Protein (aa 1-212) (strain SM101 / Type A)
SKU: VAng-Lsx00705-50gEcoli|Size: 50 µg (E. coli)

50G Dextran Sulfate
SKU: NAT1236|Size: 50 g

pMRNAxp mRNAExpress Vector
SKU: MR000PA-1|Size: 10 µg

FNC Coating Mix®, 50 ml
SKU: 407|Size: 50 mL

FNC Coating Mix®, 100 ml
SKU: 0407|Size: 100 mL

FNC Coating Mix® - Human Proteins, 100ml
SKU: 0407H|Size: 100 mL

Cell Attachment Reagent (FNC Coating Mix, BRFF AF-10)
SKU: MBS653072-01|Size: 100 mL

McAb to PIC (Coating)
SKU: E67X00201|Size: 100 µg

Rotating Mixer; Four-Dimensional Rotating Mixer
SKU: E0077|Size: 1 Unit

Oscillating Mixer
SKU: E0078|Size: 1 Unit

Cell Attachment Reagent (FNC Coating Mix, BRFFTM AF-10)
SKU: C2605|Size: 100 mL

FNC Coating Mix®
SKU: AES-0407-100|Size: 100 mL

FNC Coating Mix® – Human Proteins
SKU: AES-0407H-100|Size: 100 mL
