Alatrioprilat

CAT: 0804-HY-117607Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-117607Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Alatrioprilat is an orally active inhibitor of angiotensin-converting enzyme (ACE) (IC50=19.6 nM; Ki=9.8 nM) and enkephailnase (IC50=6.1 nM; Ki=5.1 nM) . Alatrioprilat plays a key role in the metabolism of hormonal peptides through the degradation of nitric oxide and atrial natriuretic factor (ANF) . Alatrioprilat can be used in the study of cardiovascular diseases[1].

CAS Number

135038-59-4

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE) ; Neprilysin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/alatrioprilat.html

Smiles

OC([C@H](C)NC([C@@H](CS)CC1=CC=C(OCO2)C2=C1)=O)=O

Molecular Formula

C14H17NO5S

Molecular Weight

311.35

References & Citations

[1]Gros C, et al. Mixed inhibitors of angiotensin-converting enzyme (EC 3.4. 15.1) and enkephalinase (EC 3.4. 24.11) : rational design, properties, and potential cardiovascular applications of glycopril and alatriopril[J]. Proceedings of the National Academy of Sciences, 1991, 88 (10) : 4210-4214.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Alatrioprilat

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