YTHDF1 Polyclonal Antibody

CAT: 0866-RD90234A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD90234A-01Size:60 μL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Specifically recognizes and binds N6-methyladenosine (m6A-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3 shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity. Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity. Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity. In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity.
Description
This is a YTHDF1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
YTHDF1, C20orf21
Gene ID
54915
Swiss Prot
Q9BYJ9
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human YTHDF1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
47-48kDa/62-97kDa
Observed Molecular Weight
67kDa
Host or Source
Rabbit
Isotype
IgG

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